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The functions of many long noncoding RNAs (lncRNAs) in the human genome remain unknown owing to the lack of scalable loss-of-function screening tools.
The molecular organization of and mechanistic events that take place in the PLC are unknown owing to the heterogeneous composition and intrinsically dynamic nature of the complex.
However, whether TERRAs regulate H3K27 deposition at telomeres or, more generally, whether TERRAs have a direct role in the establishment of telomeric chromatin status is largely unknown owing to the lack of KO models for TERRAs.
While qualitative studies have demonstrated the proximity of neck muscles to the cervical facet capsule, the magnitude of their forces remains unknown owing to a lack of quantitative muscle geometry.
Exactly how many jobs Bain Capital added compared to those lost because of these investments and buyouts is unknown, owing to a lack of records and Bain Capital's penchant for privacy on behalf of itself and its investors.
Neville's activities during the years immediately after 1207 are unknown, owing to the lack of royal records, but in December 1213 he was given custody of the Great Seal of the kingdom.
Similar(46)
However, this crisis in the making remains mostly unknown, partially owing to the fact that those impacted are often low-income immigrants whose primary language is one other than English.
Abstinence time needed for marijuana is unknown, but owing to the much longer half-life of the active agent of this drug in the body, it is likely to be longer than for alcohol.
Expanding indications for treatment beyond this group has unknown value owing to lower observed fracture probabilities and uncertain benefits of treatment and would result in overdiagnosis and overtreatment.
The specific mechanisms by which this bacterium induces nerve injury remain largely unknown, mainly owing to ethical and practical limitations in obtaining affected human nerve samples.
The strength of evidence for these findings is limited by risk of bias, inconsistency (or unknown consistency owing to limited numbers of studies within individual comparisons), and lack of precision.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com