In this week's presidential run-off in Ukraine, 41-year-old actor and comedian Volodymyr Zelenskiy, a political unknown, leads the pack of candidates.
"The effect of these particles on turtles is unknown," lead author Emily Duncan, an ecology research student at the University of Exeter, said in a press release.
That experience, and similar encounters with other patients taking herbal products with unknown ingredients and unknown effects, recommended by people with unknown credentials, led Dr. Arab to organize a scientific meeting on the subject.
It's been really good to learn about people of other religions, because the unknown leads to fear and when you know, you can relate.
French director Jacques Audiard does things his own way: his latest film stars previously unknown leads from Sri Lanka and India, and is almost entirely in the Tamil language.
It made a star out of its then unknown lead, Tahar Rahim, and contributed substantially to making French cinema a less white middle-class concern.
But in removing set pieces and characters, and focusing the story on just the two largely unknown leads, the team made the movie harder to market.
Applying this method to geographically dispersed locations might not be appropriate due to unknown leads and lags in the climate system.
It would've been easy for Bowie to have stolen the spotlight from Connelly's young, unknown lead, to use cachet and ego to press his way to the film's centre.
Close behind with 10 nods, also including ones for best picture and director, was "Slumdog Millionaire," a Fox Searchlight entry that was filmed on a relative shoestring budget ($15 million), had an unknown lead and was presented partly in Hindi.
