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Liver (108, 20%) and primary bacteremia (unknown focus) (73, 13%) were also frequent sites of infection.
We found a high mortality among patients with an unknown focus of infection.
Rasmussen et al. identified an unknown focus of infection as one of several independent risk factors for infective endocarditis in patients with Staphylococcus aureus bacteremia, and only 29.8% of our patients with unknown focus were examined with echocardiography.
Six (6%) patients had an unknown focus of sepsis and 15 (16%) had no evidence of bacterial infection.
Complicated SAB cases did not meet the criteria for uncomplicated infection, had an unknown focus or died within 72 hours.
An unknown focus of infection was assigned when none of the criteria for ascertaining a focus were met.
Similar(41)
The most common foci of infection were skin and soft tissue infections (31%), central venous catheters (23%) or unknown foci (14%) (Table 2).
IAT relates to unknown foci of origin in septic patients irrespective of the site of acquisition and severity of illness (P = 0.01, RR = 2.3).
All cases are thought to have been acquired locally, thus establishing the existence of 2 previously unknown foci (U. Ateba Ngoa et al., unpub. data).
Infections with unknown foci were noted in 11.2% of cases in the group with low invasive capacity compared to 4.2%and3.5%5% in the groups with intermediate and high invasive potential, respectively.
In line with the findings of Jansen et al., we also found that patients infected with serotypes with low invasive potential more often presented with unknown foci as a marker for more severe disease [ 4].
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