Exact(5)
The synergistic effect of RAL and HAFi on keratinocyte CD44 expression might be due either to a combined effect of RAL and HAFi on CD44 gene transcription or to a presently unknown feedback mechanism in order to upregulate the cell surface CD44 for internalization and degradation of increased HA in interkeratinocyte spaces.
However, this was not due to a decrease in HSF1 levels due to as-yet unknown feedback mechanisms (Fig 5C).
The A isoform is expressed in more specific contexts, activates NF-κB strongly but is downregulated by a unknown feedback mechanism at the protein level.
We therefore conclude that it is possible that: (a) inhibition of ERK may lead to activation of the ubuiqitination pathway and subsequent degradation of p-SFK or (b) there is an unknown feedback mechanism linking ERK1/2 and SFK phosphorylation.
Additionally, there can be cell line specific differences or thus far unknown feedback mechanisms, for example a feedback from Cyclin D1 to MEK1 or from ER-α to AKT1.
Similar(55)
However, it is unknown how feedback on multiple-tier items can improve learning success.
As an example, drugs used for inhibiting a specific signaling protein in order to affect proliferation may actually activate the pathway by triggering an unknown negative feedback loop [25].
We hypothesize that unknown global feedback mechanisms might have played an essential role in transcriptome evolution for thermal adaptation.
These novels raise the questions "What is an author?" and "What is a book?" With a cell-phone novel, an author is an anonymous figure, sometimes working collaboratively with unknown fans — whose feedback sometimes influences the plots — and a book is a product bought as the souvenir of an online reading experience.
The control system includes a state predictor for generating the estimates of the unknown parameters for feedback.
The on-line closed-loop optimization strategy uses a descending horizon dynamic optimization algorithm based on nonlinear programming and an additive unknown disturbance for feedback.
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