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The study supports application of miRNA expression as a biomarker for identifying the genotoxicity and carcinogenicity of AA and other of unknown exposures.
In 2005, a Herlev resident physician, concerned that unknown exposures caused 10 CKD patients to develop NSF, requested assistance from the Board of Health epidemiologists [ 12].
Recent untargeted metabolomic studies have applied this top-down approach to identify hitherto unknown exposures associated with cardiovascular disease (Holmes et al. 2008; Wang et al. 2011).
This is most relevant for the EU-biomonitoring program where samples from different exposure groups may provide useful information about past exposures to hitherto unknown exposures to new compounds.
However, to measure DNA damage comprehensively, which is required by the systems toxicology paradigm, a new top-down DNA adductomics approach is required that can simultaneously screen for multiple DNA adducts derived from known and unknown exposures and from biological responses to exposures such as induced formation of endogenous electrophiles.
Conceivably, Cmap could be used in conjunction with preexisting gene classifiers to make predictions on field samples with unknown exposures, validate candidate gene classifiers using pre-established reference GEPs, categorize environmental stressors into a more manageable number of chemical classes based on pathways affected, and link chemical stressors to their apical biological endpoints.
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But they are punishing companies that come to market with unknown exposure to potentially toxic credit derivatives.
Mitsunaga and Nayar [29] perform an iterative polynomial regression, where the (assumed to be unknown) exposure time ratio Δ t j / Δ t j ′ is refined in each iteration.
Unknown exposure setting was reported for 434 (39.3 %) of cases.
Unknown exposure setting was reported for 37.9 % of cases.> -wrap-foot> Of the 1,336 S.
This fact caused a question about some unknown exposure to infectious pulmonary TB.
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CEO of Professional Science Editing for Scientists @ prosciediting.com