Exact(19)
In Vietnam, a Sydney man faces the prospect of secret execution by lethal injection of locally manufactured chemicals of "unknown efficacy", according to Amnesty International.
They can give toxic drugs of unknown efficacy, operate to try to remove part of the tumor, put in a feeding tube if a person can't eat: there's always something.
"We've taken a drug that has very limited risk and replaced these drugs, often with a class of drugs that have unknown efficacy but quite well-known risks," says Thomas R. Insel, director of the National Institute of Mental Health.
The ethics panel, made up of researchers, ethicists, and patient safety advocates, reached consensus that under certain circumstances in this outbreak, "it is ethical to offer unproven interventions with as yet unknown efficacy and adverse effects, as potential treatment or prevention".
Reporting on the deliberations, the WHO panel reached consensus that it is ethical to offer unproven interventions -- with as yet unknown efficacy and adverse effects -- as potential treatments or prevention efforts.
For instance, fears have been expressed that, in Nigeria, witchcraft and traditional remedies of unknown efficacy are widely employed as treatments for malaria, instead of, or delaying access to, modern medicines of proven effectiveness [11].
Similar(41)
We know of several techniques for PRP preparation, with multiple commercially available products (Table 2); however, their application has been confusing because each technique leads to a different product with potentially dissimilar biology and unknown relative efficacy.
Some authors have also used topical amphotericin B irrigations into the postoperative sinonasal cavity, although optimal dosing is unknown and efficacy is difficult to determine distinct from other concurrent therapies.
Although adherence to an ARV prevention option will be less obscured by unknown safety and efficacy of a study product, how will healthcare providers and users interpret the level of efficacy?
pylori ulcer is largely unknown and the efficacy of acid suppressants in the management and prevention of the disease remains to be defined.
It is unknown whether the efficacy and safety profiles observed with MK-0941 were compound specific or mechanism based.
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