In the controller design process, all the nonlinear unknown functions are accumulated to the last step in each subsystem, and the final nonlinear unknown accumulation is approximated by using generalized fuzzy hyperbolic model (GFHM).
During the course of infection, CWD prions accumulate in lymphoid tissue and the central nervous system and, although the mechanism of pathogenesis is unknown, accumulation of CWD prions in the body coincides with tissue damage and eventual host death [6], [7].
The rest of the 70% deficit is considered to be relaxed by aseismic slips along the subduction zone, or accounted for by some unknown stress accumulation which has been in effect for more than 1000 years (Kanamori et al., 2006).
6– 8 Although the pathogenesis of PD is still unknown, the accumulation of α-synuclein and other ubiquitinated proteins in Lewy bodies has implicated protein mishandling as a putative cause.
The pathological consequences of this altered process in the context of long-term methylphenidate abuse are still unknown, although accumulation of unnecessary proteins resulting from a defective ubiquitin dependent proteolysis has been shown to contribute to aggregation events, a pathogenic mechanism in several neurobehavioral and neurodegenerative disorders [ 58, 59].
For few mRNAs, we observed previously unknown ovary accumulations, for example mRNAs in cytoplasmic granules (CG17494), depleted from the oocyte (Nacalpha), showing cortical enrichment (Actn), or forming ring-like structures (CG14639, Figure 1B', Figure 2 figure supplement 1E).
However, it is unknown whether protein accumulation harms the function of the UPS or whether the failure of the UPS leads to protein accumulation.
It is currently unknown how asymmetric accumulation of cell polarity marker proteins is regulated in the notochord plate along the dorsoventral axis.
The function of this stable RNA species is currently unknown, but its accumulation has been described in several human mitochondrial pathologies (Suzuki et al., 2011).
At present, it is unknown whether cytoplasmic accumulation of the mutant forms of ApoA-I is the reason for their cytotoxicity.
Although there is ample evidence that IRBC do accumulate in tissues, the mechanism of accumulation is unknown [26] [28].
