When occurring in the eye, angiogenesis clearly proved to represent a threaten, whereas an univocal interpretation of the action of angiogenesis on the inner ear homeostasis is still lacking despite the morpohologic and functional analogies between eye and labyrinth.
Despite the possible association between migraine and arterial hypertension is an old issue, data still do not prove an univocal interpretation of the co-occurrence of these two conditions.
The evaluation of a risk by the Index Method allows a univocal interpretation of the hazards of an existing plant, related to the intrinsic characteristics, the chemistry, and the environmental conditions, allowing to characterize every unit by a global risk index.
It is very difficult to suggest a univocal interpretation of the observed data.
Although the Guidance is clear enough and take into consideration a lot of important topics on PRO instruments (their development, assessment of measurement properties, modification of existing instruments), study design and data analysis, it could be improved to make it more applicable to NDA trials and facilitate univocal interpretation of results by experts and regulators.
So far, several preclinical studies have been published trying to address this aspect for the sensitivity to MEK inhibitors, but, since different results have been reported, no univocal interpretation could be made (Balmanno et al, 2009; Dry et al, 2010; Garon et al, 2010; Tendler et al, 2010).
Despite the great contribution that these imaging technologies have provided to the knowledge of morphologycal features in persons with ASDs, the unique phenotypic trademarks of these disorders create peculiar difficulties in designing imaging studies that provide data with univocal interpretation and new insight into the pathogenesis of these conditions.
Persons with ASDs can manifest various cognitive abilities and in several prior studies, this has produced confounding findings and non-univocal interpretations.
As pointed out by other authors [7, 40], MAD results contain a high degree of detail, but don't give a univocal possibility for the semantic interpretation.
Kratzer (1983) treats modals as univocal but indexical: they get their differing interpretations by taking in different input sets of worlds and orderings induced on the relevant sets.
That being so, an important question arises about Schlick's interpretation of Einstein on the univocal determination of spacetime events as spacetime coincidences.
