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Since the median year of publication for our trials was 2004, recent initiatives such as universal trial registration and the Standard Protocol Items for Randomized Trials (SPIRIT) initiative may improve this in the future [11]; [11].
Six different programs were studied in one universal trial each.
In previous studies, the PRP program has never been tested in a strictly universal trial with a randomized design.
DRKS00003431 WHO Universal Trial Number U1111-1126-0718 The heandh and education of children are a public good that lies at the core of government policies and programmes.
Universal Trial Number U1111-1125-2149 registered on 13/10/2011; Australian New Zealand Clinical Trials Registry Number ACTRN12611001097932 registered on 21/10/2011.
Trial registration numbers for the LowSALT CKD study are: Universal Trial Number U1111-1125-2149, aNew Zealandan New Zealand Clinical Trials Registry Number ACTRN12611001097932.
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To conclude, evidence regarding the effectiveness of universal trials is inconsistent.
Results regarding effect of universal trials are summarized in Table 2.
The number of participants in the respective trials varied from 100 to 998, with the largest samples recruited for universal trials.
However, some universal trials that include more than 70% of the addressed population are effective in preventing depressive symptoms [ 59, 60].
PRP has shown to be less effective in universal trials and when delivered by other professionals rather than the research team members [ 15].
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