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GGAs are monoubiquitinated at their GAT (GGA and TOM) domain, which supports the idea that ubiquitin is a universal sorting signal, acting at various intracellular sites.
These data suggest that LERP is dispensable for intracellular retention of dCREG, indicating that LERP is, unlike its mammalian relatives, not a universal sorting receptor for lysosomal proteins in flies.
Although universal sorting signals for membrane proteins that allow for compartment-specific targeting are largely unknown, it has been demonstrated that the length of the TMD provides sufficient sorting information for targeting type-I proteins either to the ER, the Golgi or the PM [ 48].
Most recently, Kowalewski-Nimmerfall et al. reported that RNAi knockdown of LERP in S2 cells had only a small effect on the retention of the lysosomal enzyme cathepsin L and no effect on lysosomal CREG (cellular repressor of EIA-stimulated genes retention), leading them to suggest that LERP is not a universal sorting receptor for lysosomal proteins in flies (Kowalewski-Nimmerfall et al., 2014).
Similar(56)
At that moment the emotion translated through the television screen; it didn't hurt that the camera went to the obviously moved George and Barbara Bush, beaming with the most universal sort of parental pride, sitting there as icons to nudge the emotion along.
Mercedes, by contrast, is tops for making a universal sort of luxury, appealing equally to both genders without seeming generic.
The main idea here is that while moral sentences do in fact express a species of prescription much as ordinary imperatives do, they express prescriptions of a special universal sort.
Hence, the SP phenotype has been suggested as a potentially universal CSC sorting marker, although it also has the limitation on accuracy for sorting pure CSC-like populations.
Some of the music that Pink Floyd has done is like part of our DNA, it's part of what music is to people, not because of Pink Floyd, but because it's universal -- sort of simple, powerful sounds.
Corbyn represents something altogether woollier, a sort of universal university campus, where a benign but powerless leader promises the earth.
It's also not clear if other labels would be involved, or if this would be a Universal-only sort of deal (which would also doom it to failure).
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Justyna Jupowicz-Kozak
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