In their universal manifestation in graffiti and in ancient murals, such as cave paintings and protodynastic Egyptian frescoes, symbols and representational images have been spread freely and indiscriminately across walls, ceilings, and floors.
One can superficially maintain that no contradiction is involved in the act of struggling (i.e., willing) to deny the will-to-live, because one is not saying that Will is somehow destroying itself, but only saying that a more universal manifestation of Will is overpowering a less universal manifestation, namely, the natural, individuated, physically-embodied aspect.
Proteinuria was a universal manifestation, and kidney insufficiency was present in 54% [ 52].
These findings raise an interesting question as to whether a reduction in histone biosynthesis is a universal manifestation of cellular aging across eukaryotic species.
Fibrosis is the main and most universal manifestation of SSc, which is caused by the unbalanced state between ECM production and degradation.
Sepsis syndrome is a common but not universal manifestation of melioidosis in humans; chronic melioidosis, in particular, may not be associated with significant systemic inflammation.
Systemic sclerosis (SSc) is a connective tissue disease mainly characterized by extensive fibrosis in skin and internal organs, such as lung, heart, esophagus and kidney, among which skin fibrosis is the universal manifestation in SSc [ 1, 2].
The universal bodily manifestations of disgust evolved to help humans avoid ingesting toxins and other harmful substances, while the more cognitive or symbolic sense of offensiveness and contamination associated with disgust evolved to help humans avoid diseases and parasites.
The simplest interpretation of our clinical observations is provided by the notion that the cerebellum is an extremely sensitive organ to oxidative stress and energy metabolic disorders, consistent with the near-universal demonstration of cerebellar manifestations even in cases of mild CoQ deficiency [ 11, 13].
