Sentence examples for universal cardiac from inspiring English sources

In developing a universal cardiac differentiation system, we evaluated and tested the strengths of multiple published protocols with a multivariate strategy.

We first hypothesized that promoting uniform growth of undifferentiated hPSC lines is critical for subsequent reproducible differentiation and for the derivation of a universal cardiac differentiation system.

The development of a universal cardiac differentiation protocol that can translate across multiple pluripotent stem cell lines allows immediate application to genetically diverse hiPSC lines created from patients with cardiac related diseases (e.g. long QT syndrome [50], [51]).

We used this data to develop a universal cardiac differentiation system that has an average efficiency of 94.7±2.4% hEB contracting for a diverse repertoire of hESC lines and hiPSC lines, including those generated from fetal fibroblasts using lentiviral methods, or neonatal CD34+ cord blood cells and mature-donor dermal fibroblasts using non-viral episomal-based methods.

We further identified a core set of genes that might represent a universal maladaptive cardiac response to stress and provide individual gene candidates for further investigation.

Two decades later, despite an almost universal awareness of cardiac surgeon report cards, their impact on referral practices still remains limited [13].

This efficient and cost-effective universal system for cardiac differentiation of hiPSC allows a potentially unlimited production of functional cardiomyocytes suitable for application to hPSC-based drug development, cardiac disease modeling, and the future generation of clinically-safe nonviral human cardiac cells for regenerative medicine.

Metabolic acidosis is an almost universal feature of cardiac arrest.

This is surprising since Belgium and US Medicare are characterized by a generous universal coverage and distances to cardiac services are less relevant at this stage.

Although originally described for witnessed intraoperative arrests, closed chest cardiac massage quickly became universal practice, and a legal imperative in many hospitals.

Its universal definition - rise or fall (or both) of cardiac biomarkers, preferably cardiac troponin (cTn), above the 99th percentile of the upper reference limit associated with clinical, electrical, or imaging symptoms of ischemia [ 2] - has limitations in the ICU.