The waveform of compound synaptic potentials as a result of spatial summation of unitary potentials that were evoked simultaneously at 94 synaptic terminals in the present simulation was found to be critically affected by the distribution pattern of active conductances.
Considering Mars a spherically symmetric body, for a given conductivity profile, a forward calculation at a given frequency ω of the internal induction process for a unitary source potential of strength 1 and SH geometry l, m provides the model's response Q l.
It should be noted here that, regardless of how the active conductances were distributed, the temporal profile of the unitary synaptic potential at the dendritic terminal where the activated synapse was located was not affected at all by active conductances even when the membrane potential exceeded the activation level for three types of potassium conductances [15].
The results on unitary synaptic potential evoked at a dendritic terminal on the side ipsilateral to the soma (Fig. 2A) showed that the spatio-temporal spread of the potential remained unaffected whichever distribution pattern was implemented in the model including the uniform distribution over dendrites.
Data were analyzed and curve fitting performed using Axograph X. Unitary postsynaptic potential (uPSP) onset time, rise time, and half-width was measured from either single episodes or from averages (usually 50 responses).
The reduction in [18], [17], [16] provides the average firing rates of the different neuronal populations when: i) the number of neurons is infinitely large, ii) the unitary postsynaptic potentials elicited by presynaptic spikes are infinitesimally small iii) neurons from the same population share the same statistics of the input.
Lastly, CR cells are biased toward targeting dendritic shafts compared with spines, and produce large-amplitude glutamatergic unitary postsynaptic potentials on γ-aminobutyric acid (GABA) containing interneurons.
In dual whole-cell voltage recordings from pyramidal neurons, the coincidence of postsynaptic action potentials (APs) and unitary excitatory postsynaptic potentials (EPSPs) was found to induce changes in EPSPs.
In the four bursting cells of the left upper quadrant the rhythm is modulated by a unitary inhibitory postsynaptic potential; in the bursting cell of the right lower quadrant the rhythm is modulated by a unitary excitatory postsynaptic potential.
uPSP responses (uEPSP or unitary inhibitory postsynaptic potential (uIPSP)) were normalized to the first response (uPSP1) in the train.
