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Striving for a simple, unitary explanation of disease, he conjectured that all diseases are really one a fever brought on by overstimulation of the blood vessels and hence subject to a simple remedy—"depletion" by bloodletting and purges.
Thus, throughout its founding period, ecological genetics was relentlessly supportive of natural selection as unitary explanation for evolutionary change.
He then showed that, if one assumed only the unitary explanation of natural selection, then the observed gene frequency fluctuations were so large even without the sampling variance that the temporal variations in the allelic selection coefficients must range from near lethality (or sterility) to tremendous advantage (i.e., -0.50 to +0.50).
However, some authors have suggested that the triad of core symptoms may, or even cannot, have a unitary explanation and should instead be fractionated and studied separately [81].
Mechanisms involving genetic, environmental and physiological interactions 22– 23 have been proposed to account for this association, but a unitary explanation has yet to be identified.
At first glance, this unitary explanation appears attractive because TAGs of wild-type N2 worms are enriched for the shortest-chain FAs (C14 0 and C15- iso) and some MUFAs, but have less C18 0 and PUFAs than are present in the phospholipid fraction [ 24].
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Dreyfus and Kelly say that we should have the courage not to look for some unitary, totalistic explanation for the universe.
This question (Q2) helps to avoid the confusion that arises from trying to posit unitary evolutionary explanations for things like war or liking miso soup.
Treisman herself has suggested, albeit tentatively, that descendants of the Feature Integration Theory may provide part of the explanation for "the bound, unitary, interpreted, personal view of the world of subjective experience" (Treisman, 2003, 111).
Both James Cushing (1994) and Mara Beller (1999) take for granted the existence of a unitary Copenhagen interpretation in their social and institutional explanation of the once total dominance of the Copenhagen orthodoxy; a view they personally find unconvincing and outdated partly because they read Bohr's view on quantum mechanics through Heisenberg's exposition.
This "crack" is universal: humanity will always be reconciled to life as it is while, at the same time, longing for a simple, unitary truth, underlying existence, that provides a deep and consoling explanation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com