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To address the challenge of multiple administrative areal units, we applied GIS-based techniques to derive and validate area-weighted prevalence estimates at a common unit of analysis.
In order to create balanced treated and control pairs of units we apply the Genetic Matching method [36].
Participating doctors were the primary sampling unit, and we applied the survey commands of Stata (release 8).
Since the cost of a nurse phone consultation was not reported in the national unit cost report, we applied the relative difference between the cost of a physician and a nurse visit to the cost of a physician phone consultation to obtain the cost of a nurse phone consultation (31.50/71.30×20.00=€8.84).
For indexing the different mesophases and calculating the corresponding unit lattice parameter a, we applied the respective reflection laws for the cubic and the hexagonal phases [8].
For all other modeling we applied unit variance (UV) scaling.
We applied unit costs to the resource use data in the LASER-AD study (see online supplementary table S1).
16 We applied unit costs from routine sources 17 18 in 2011 UK£ and calculated 3-month costs for each participant at each follow-up point.
To obtain three month costs for each participant at each assessment point we applied unit costs (see web extra on bmj.com) to data on resource use at individual level as recorded on the client service receipt inventory.
To account for the facts that some applicants made a tender for several concessions, and several concession units had multiple applicants, we applied Generalized Estimating Equations (GEE) to account for the respective correlation structure in the models for the area-based fees offered by the applicants, and for the probability of the applicants for winning the solicited concession unit [25].
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