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Therefore, emphasis was put on the elucidation of the response of different isoforms in phenotypically distinct muscles and the influence of slow/fast motor unit stimulation frequencies.
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The developed system consists of a stimulator unit, stimulator firmware, external sensors, a programmer unit, two stimulation channels and electrodes.
To test whether the suppressive interactions resulted from GABAA-mediated inhibitory processes, we examined the effect of iontophoretic application of BIC on the responses of single AI units to stimulation with two simultaneously presented AM tone complexes in a total of 27 units.
This follows from Weber's Law: 10 additional units of stimulation makes a big difference to sensation at the bottom end of the scale, but a progressively smaller difference as we move towards the top.
The middle column (C,D) shows the responses of the same units during stimulation with two simultaneously presented AM tones.
Both units of stimulation (real or sham) will be applied, using four self-adhesive electrodes (VALUTRODE 5 × 9 cm).
It is unclear which CaMKII isoforms mediate these effects in skeletal muscle but their autophosphorylation pattern in response to fast or slow motor unit-type stimulation might provide clues about CaMKII isoform-specific functions.
CaMKII autophosphorylation at Thr287 was assessed in three muscle compartments of the rat after slow or fast motor unit-type stimulation and was compared against a computational model (CaMuZclE) coupling myocellular calcium dynamics with CaMKII Thr287 phosphorylation.
We used a Grass Instruments (Quincy, MA) S88 stimulator in series with a Grass Instruments CCU1A constant current stimulus isolation unit to deliver stimulations.
The needles were left in situ and connected to an electrical stimulation unit.
The optical stimulation unit consists of four high power LEDs fitted in four channels and optically focused on the sample.
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