Only 0.5% of the ratios in this direct comparison deviate from the median by >4.88 MAD units when MAD is calculated over the entire array, whereas 2.2% do when MAD is calculated over the 97-clone region.
In each plot, we have highlighted clones that deviate from the overall median by >4.88 median absolute deviation (MAD) units, with MAD calculated using the data for clones in a region of 1q that showed the least biological variation within and across experiments (see Methods).
In the 1940s and '50s, the unit chased the Mad Bomber, George Metesky, as he waged his battle against Con Edison with dozens of explosive devices.
This clone gave a high ratio only in arrays for heart versus spleen (>9 MAD units above the median) and cerebellum versus spleen (4 to 8 MAD units above median).
These conservative classifications correspond to BACs with ratios on the methylation-sensitive arrays that exceed MAD-based thresholds discussed above (that is, for Figure 7, 4.88 MAD units from the median, a threshold chosen such that we would expect approximately 0.05% of BACs on the array to fall in each of the Low or High categories by chance).
These outlying values, marked in each methylation profile, should include loci having true methylation differences between samples, since only 0.1% of the ratios drawn from a normal distribution (that is, two false-positive clones per array) are expected to deviate from the median by >4.88 MAD units.
We identified clones anywhere on chromosome 1 whose average log2 ratio values deviated below or above the overall median by >4.88 MAD units (that is, >3.29 times the SD), which would correspond to deviations with statistical significance at the predictive value of 0.001 based on a normal distribution with two-sided P value.
The other lead actress nominees are Kyra Sedgwick for "The Closer," Glenn Close for "Damages," Mariska Hargitay for "Law & Order: Special Victims Unit," January Jones for "Mad Men" and Julianna Margulies for "The Good Wife".
But when an opposing defense doesn't respect the possibility of a long pass downfield, it's easier for it to cover short passes, particularly a Patriot defensive unit coached by the mad scientist of pass defense, Bill Belichick.
AUDI Seemingly answering Mercedes-Benz's power-mad AMG unit, Audi cranked up the RS7 and SQ5.
His unit has traded in its "Mad Max" pickup trucks for a captured loyalist tank and a pair of brand-new, armored personnel carriers that they said were donated by Qatar, an early ally of the rebels.
