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The occurrence of large numbers of insertion sequences or other repetitive elements would be uniquely problematic in de novo assembly of contigs and a very high GC or AT content would increase problems with homopolymer sequencing errors and repeat sequence assembly errors due to lower overall sequence complexity.
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But while the concept of food addiction is controversial among researchers, there is growing evidence that highly-processed, fatty, sugary foods like pizza, chocolate, chips and cookies as uniquely problematic foods in people's lives.
Others argue, though, that Apple's culture has become uniquely problematic and is getting in the way of innovation.
The out-group feature of religion is uniquely problematic: faith separates people in a deep, fundamental way.
Including Iran in the bill is also uniquely problematic because doing so breaks America's promises under the JCPOA (aka Iran Nuclear deal).
And as for the idea that people might be registered to vote in two states ― which Trump surrogate Kris Kobach, the Kansas secretary of state, highlighted Monday in a CNN interview as uniquely problematic ― that is merely a reflection of current demographic realities.
In this regard, there is nothing uniquely problematic about the social psychology scenarios; indeed, the Woolfolk et al. vignettes are relatives of the "Frankfurt-type cases" which have spawned a massive and fecund philosophical literature (see Fischer and Ravizza 1998), and they certainly don't seem outlandish by the standards current there.
But the employees believe AJE's uniquely problematic circumstances made such an action particularly unwise.
And so I think that makes them uniquely problematic.
This organism is uniquely problematic because of a combination of inherent resistance to many drug classes and its ability to acquire resistance to all relevant treatments [ 3].
"London is uniquely unique in its uniqueness, a uniqueness unique for being uniquely singular in its unique qualities".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com