These results collectively indicate that microenvironmental factors can uniquely modify the phenotype of differentiated recruited monocytes inducing marked changes in mRNA levels and also in miRNA expression and kinetics that may modulate the remarkable flexibility of monocyte responses to specific environmental cues.
Dedifferentiation of fully differentiated cells is not uniquely restricted to malignant cells, but upon damage or imbalance in tissue homeostasis, also normal mature cells can reprogram into a stem cell.
Retroviral gene therapies increasingly utilize vectors based on HIV, which is in the lentivirus family and is uniquely efficient at transducing nondividing and terminally differentiated cells.
Here we report on the healing of both critical-sized (5 mm) and massive (15 mm) full-thickness femur defects in rats by implanting a uniquely fabricated PLGA scaffold seeded with MSCs pre-differentiated in vitro into cartilage-forming chondrocytes (MSC-DCs).
In addition, we uncovered a new source of biological variation (i.e. reducing ALCAM expression), which suggests that well differentiated tumors may adopt a more aggressive phenotype uniquely among AA women.
DNA repair is uniquely critical in stem cells as mutations accumulated in stem cells amplify in differentiated daughters.
Severin Schwan, the chief executive of Roche Diagnostics, said on Monday, "Our combined company will be uniquely positioned to develop companion diagnostics which enable the identification of patient responses to treatments, thereby offering more cost-efficient, differentiated and targeted medicines to patients".
"It is uniquely challenging".
