This appears to have been the case for the outbreak of multi-drug resistant TB in New York City in the early 1990's, which was later shown to be a unique variant of the W-Beijing strain family [9].
In P. falciparum, the only uORF described and functionally characterized to date is a 120 codon region upstream of the var2csa (PFL0030c) coding region, a unique variant of the surface antigen PfEMP1 that mediates adhesion to placenta in pregnant women (Amulic et al., 2009).
Homozygosity for a SLC39A13 loss of function mutation was detected in sibs affected by a unique variant of EDS that recapitulates the phenotype observed in Slc39a13-KO mice.
T cells are key components of the immune system, and each has a unique variant of a signalling complex known as the T cell receptor on its surface.
We call one such unique variant of one such organism a "self".
A unique variant of 6-phosphofructo-2-kinase/fructose 2,6 bisphosphatase (PFK2/F2BP), a regulator of glycolytic flux previously uncharacterized in single-cell photosynthetic eukaryotes, was identified in diatom genomes and overexpressed in Thalassiosira pseudonana.
In the 2007 WHO classification, ETANTR was only discussed as a possibly unique variant of CNS tumors [ 14].
In addition, "embryonal tumor with abundant neuropil and true rosettes" (ETANTR) has been discussed as a possibly unique variant of CNS PNET [ 1, 2, 4, 6, 8, 10, 11, 19].
12, 13 This picture shows close similarity with TMEV infections of mice, which are widespread in nature and cause very sporadically an MS-like chronic demyelinating illness, actually only when genetically susceptible mice become infected by a unique variant of TMEV.
Galizia et al. reveal an overrepresentation of unique variants of CHD2 — which encodes the transcriptional regulator 'chromodomain helicase DNA-binding protein 2' — in photosensitive epilepsies, and show that chd2 knockdown in zebrafish causes photosensitivity.
Figure 4 illustrates a global sequence alignment containing vertebrate SBP2, SBP2L from all of the 17 species that we have identified as possessing complete SBP2L sequence, and unique variants of SBP2 from I. scapularis and T. adhaerens.
