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"It will be a unique trial".
As one former judge here said: "It's going to be a unique trial".
N-of-1 trials are a unique trial design which can inform personalized evidence-based decisions for the patient when data from traditional clinical trials are lacking or not generalizable.
Forty years ago, a young Seattle cardiologist named Leonard Cobb conducted a unique trial of a procedure then commonly used for angina, in which doctors made small incisions in the chest and tied knots in two arteries to try to increase blood flow to the heart.
The composite similarity score was calculated for each unique trial by taking the average Euclidean distance in MDS space between a given change and each of the background sounds presented within a particular scene.
In a unique trial scientists from Sheffield Hallam University have joined forces with West Yorkshire Police to analyse fingerprints taken from crime scenes for substances hidden within or on the print.
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The temporal occurrence of gamma bursts on a particular site was only weakly correlated across trials, but gave rise to a unique trial-averaged temporal profile per site (Supplementary Note).
Between 1973 and 2010, 47 unique trials were identified with eight trials of prospective design.
At The Gabba, Trott withstood the unique trials of technique and temperament which make batting at No3 so demanding.
MAIN RESULTS Eleven papers describing 10 unique trials met the inclusion criteria.
The stronger learning seen in this experiment compared with Experiment 1 may be attributed to the use of fewer unique trials and more repetitions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com