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Altogether, our results summarized in Figure 11 reveal how memory CD8+ T cells unique trafficking properties associated to splenic anatomy result in the formation of transient granulomas-like effector clusters in the RP of secondary infected animals.
An intriguing impact of PAR1-PAR2 heterodimer formation on signalling has come from work in the Trejo laboratory [ 152] indicating that PAR1 and PAR2 form a heterodimer that exhibits unique trafficking and signalling behaviours compared with receptor protomers.
For HTS, we chose Lgr5 as a prototype since we are interested in its unique trafficking properties, its role in stem cell biology and cancer, and its history as a difficult target to study.
We have identified a unique trafficking pathway selective to PBAEs that, upon being misregulated, has a drastic effect on the ability of the polymer to deliver DNA inside cells.
Combined with other organelle destinations such as mitochondria, digestive vacuoles involved in hemoglobin catabolism in P. falciparum, and plant-like lytic vacuoles in T. gondii (Miranda et al., 2010), specificity of protein and lipid components of these various organelles suggest a need for unique trafficking pathways mediated by distinct protein machinery.
Although originally considered as cellular debris, it now becomes clear that exosomes are not a result of casual sampling; instead, they contain selective loads via dedicated packing mechanisms [ 8 ▪, 9 ▪], deliver these loads to targeted cells and contain unique trafficking probabilities.
Similar(54)
Traffic Droid explains the title of one video, Balls For Breakfast, in which his unique traffic-enforcement style inspires one driver to describe how he'd like to splatter Traffic Droid all over the road.
The diminutive hauler was designed with India's narrow urban alleyways and unique traffic challenges in mind, and it reportedly gets nearly 42 miles per gallon with its 63-horsepower 2.5-liter 4-cylinder diesel engine.
Flickr has mind share; Yahoo Photos is driving real (unique) traffic.
The need to go mobile was pressing, as Wine.com reported that over 7% of its unique traffic came from iPhones alone (out of 8% smartphone traffic).
Note that scenarios represented by S F 1,F and S U 1,F are identical, thus leading to an overall of 72 unique traffic scenarios.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com