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Increased production of FN is one of the most typical features of senescent cells [177], [178] and potentially is an antigenic determinant unique to cellular senescence [179].
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These sequence blocks are either universal, with recognizable homologs within all cellular domains or unique to particular cellular domains.
Overall, a greater number of mRNA species were unique to the global cellular fraction and were not found within the RISC in U-87 astrocytoma (p<0.01, log2 fold change >±2.5).
Upon normalization of significant (p<0.01) U-87 miRNA microarray values to primary astrocyte miRNA microarray values, RISC-specific miRNAs could be identified and separated from miRNAs that were unique to the global cellular milieu (i.e. were not a part of RISC) in U-87 astrocytoma cells (Figure 3D).
Our study has important implications as targeting c-Myc has unique benefits specific to cellular compartments in models representing cellular heterogeneity.
L22 is unique to eukaryotes and its cellular function has yet to be clearly defined.
Because the known cellular features unique to haplo-diploid development are restricted to the germ-line tissues, we further focused our analyses on the testis and ovary.
In addition, rare subpopulations of circulating lymphocytes can be examined for signaling status in a multiparameter fashion using many fluorochrome conjugated antibodies to surface proteins to identify multiple subsets and/or many different phosphospecific antibodies to unique cellular proteins.
Moreover, the neuropathological variability observed among prion strains may result from a selective targeting of a strain-specific PrPsc complex to unique cellular or extracellular sites within the brain [17], [19], [20].
Within anergic T cells, however, E3 ligase expression is increased and/or E3 enzymes are directed to unique cellular compartments during antigen stimulation.
Distinct sets of Wnt and Frizzled ligand-receptor pairs can activate different pathways and lead to unique cellular response [ 3, 4].
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