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Finally, we combine the five models into a unique susceptibility map with a calculation of median susceptibility class.
"It's a major breakthrough" to show that APOBEC3G plays a role in humans' unique susceptibility to HIV, says Jeremy Luban, a virologist at Columbia University.
Lack of clear parallels to the Hawaiian model may reflect Hawaii's extreme isolation or the unique susceptibility of the Drepanidine radiation to exotic disease.
Our analysis of major TJ proteins revealed a unique susceptibility of ZO-1, but not occludin, claudin-1 or JAM-1, to InhA proteolytic degradation.
The ability to rapidly activate innate immune responses is likely to be critical in the containment of mycobacteria during primary infection in childhood, as evidenced by the unique susceptibility to mycobacteria in patients with Mendelian defects in interferon gamma (IFNγ) and interleukin 12 (IL-12) pathways [9], [10], [11], [12].
Apparently, each gender harbors a unique susceptibility to factors that shape the microbiota after birth.
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Our results highlight the importance of using experimental animal models to evaluate the unique susceptibilities of varying subpopulations to breast cancer risk and to ensure that risk assessments in humans do not fail to take susceptible subpopulations into account.
As outlined above (and additional details in Additional file 1: section E), co-expression changes can compromise normal functional associations between genes, thereby altering cellular response to secondary perturbations and exposing drug unique susceptibilities specifically in CQR parasites.
Furthermore, regulatory or guideline test protocols are limited in their ability to fully evaluate toxicity at various life stages, examine unique susceptibilities among vulnerable populations, efficiently assess mixtures, and provide mechanistic insight into chemical toxicity (NRC 2007; Portier 2009).
Because it is widely believed that pesticide residues accumulate in home environments, that they degrade more slowly than pesticides in fields, and that children have unique susceptibilities to and frequencies of exposure (given their propensity for hand-to-mouth behaviors and their frequent contact with floors), such a question merits investigation.
All K. pneumoniae strains causing primary liver abscess have a unique antimicrobial susceptibility pattern (resistant to ampicillin, ticarcillin, and carbenicillin but susceptible to other antibiotics including all cephalosporins and aminoglycosides) (1 – 4 ).
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