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The unique receptor specificity of influenza C virus has been used as an efficient tool to detect 9-O-Ac-Neu5Ac on the surface of various cells (Martin et al., 2003; Muchmore and Varki, 1987; Zimmer et al., 1994).
In addition, its unique receptor binding specificity with exquisite selectivity for human glycans provides an explanation for the mechanisms of host specificity of the Salmonella enterica serovars that cause typhoid fever.
These studies corroborate the notion that unique receptor proteins such as IL-11Rα, GRP78, EphA5, among others, are differentially overexpressed in tumors and present opportunities to deliver tumor-specific therapeutic drugs.
Partial proteolytic enzyme digestion revealed that, when compared with 17-β-estradiol and 4 hydroxy-tamoxifen (4-OHT) bound receptors, at least one of these compounds might induce a unique receptor conformation.
Unique receptor sequences for 826 GPCRs were derived from Uniprot, and 3D structural models were generated for each receptor's 7TM domain with the automated ICM Build Model tool (Abagyan et al. 2015) using alignment with the closest homology template (Katritch, 2013).
Only a weak but significant mRNA expression of its unique receptor CXCR4 was measured.
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Because the body contains millions of T and B cells, many of which carry unique receptors, it can respond to virtually any antigen.
Different classes of semaphorins bind to unique receptors, which include plexins and neuropilins, and receptor binding induces signaling that regulates actin dynamics [48].
Heterodimerization may create an entirely unique receptor-binding site (Jordan and Devi, 1999; Wilson et al., 2004).
We conclude that the second MAPK response enabling epithelial discrimination between C. albicans yeast and filamentous forms is independent of canonical PRR activation and is probably mediated via as yet uncharacterized or potentially unique receptor-based detection mechanisms.
In contrast to other atypical antipsychotic agents, ziprasidone, a novel antipsychotic agent with a unique receptor-binding profile, has been reported to cause minimal or no weight gain [ 2, 12- 17].
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