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Interestingly, while the basal cell signature overlaps that of basal-like cells of other organs, the human airway basal cell signature has features not previously associated with this cell type, including a unique pattern of genes encoding extracellular matrix components, G protein-coupled receptors, neuroactive ligands and receptors, and ion channels.
Specialized biological properties of a given organ or tissue are determined by a unique pattern of genes expressed in distinct cell populations typical for each tissue.
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11β-dichloro induces a unique pattern of gene disruption, induces apoptosis in apoptosis-resistant cells, and shows promising anticancer activity in animals.
In the human, decidual macrophages possess a unique pattern of gene expression as compared to monocytes [21].
Quantitative RT-PCR confirmed the unique pattern of gene expression observed by microarray analysis.
In addition, FSHD muscle progenitors had a unique pattern of gene dysregulation compared with analogous control cells.
Dose-response studies were carried out in mice for each chemical; each produced a unique pattern of gene induction.
These data greatly expand the number of genes known to be selectively expressed in cartilage and emphasize the unique pattern of gene expression that determines its properties.
Principal component analysis and hierarchical clustering identified a unique pattern of gene expression capable of distinctively classifying MSCs from other tissues and cells.
This analysis confirmed again that each of the GCs can generate both a common and unique pattern of gene expression that is associated with specific biological processes.
Although each cell line displayed a unique pattern of gene expression (Cheung et al. 2003), changes in gene expression related to cell cycle control, DNA metabolism, and apoptosis were very similar in the three lines in response to IR treatment.
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