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The rapid assembly of dimeric structures using unique modes of pyrroloindolizine reactivity presents a concise approach to the dimeric myrmicarins and relevant derivatives.
Applications range from combining two drug activities into one molecule to unique modes of action like the recruiting of immune cells to tumors.
Development of new therapies is urgently needed, either by finding new compounds with unique modes of action, or by reversing resistance towards known drugs with 'chemosensitizers' or 'chemoreversal' agents (CRA).
This flexibility provides an opportunity to increase activity, prevent the development of resistance, or introduce unique modes of action that are otherwise not attainable via standard monoclonal antibody formats targeting a single antigen.
"Through language, people preserve their community's history, customs and traditions, memory, unique modes of thinking, meaning and expression.
As both critics and artists have personal areas of interest, they tend to push the unique modes of vision associated with these areas to their limits.
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Chiba, S. & Ito, K. Multisite ribosomal stalling: a unique mode of regulatory nascent chain action revealed for MifM.
Anoikis is a unique mode of apoptosis consequential to insufficient cell-matrix interactions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com