To determine if each time point examined has a unique gene expression response within each brain region, we determined for each brain region the overlap of differentially expressed genes among the five time points, each compared to virgins.
According to the above pathway analysis, transcription factors, including glucocorticoid receptor, estrogen receptor and VDR/RXR, along with HIF played significant roles in mediating the cerebellum region-unique gene expression responses (Table 3), though this did not explain the entire cerebellum-specific response.
In sum, beige adipocytes possess distinct phenotypic and functional characteristics from white and brown adipocytes that are underlain by their unique gene expression signature in response to environmental stimuli.
For example, natural [ 23, 24] and synthetic [ 25, 26] regulatory circuits can produce unique gene expression patterns in response to distinct combinations of signals endogenous to a cell.
Microarray technology provides a rapid and cost-effective method to associate specific cellular responses with unique gene expression patterns.
Chaussabel et al.[ 20] identified the unique gene expression profiles of human macrophages and dendritic cells responses to phylogenetically distinct parasites, including M. tuberculosis H37Rv.
Our data reveal a complex transcriptional response, with individual WOAs triggering unique gene expression profiles and with important differences between acute and chronic exposure.
This ensures that those genes significant in both treatments and approaching significance in the other treatment are not considered as unique, thus increasing the likelihood of identifying treatment-specific differential gene expression responses.
Each tumour had a unique gene expression profile, consistent with individuality in both disease progression and treatment response, highlighting the potential for future development of more personalised treatment approaches.
