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The conservation and unique divergence of ADAM genes in Xenopus probably reflect the particular selective pressures these amphibian species faced during evolution.
It seems evident that formation of different enzymes by unique divergence events, add up to creation of taxa with different metabolic characteristics.
To evaluate all possible scenarios of divergence, which differ in the number of unique divergence parameters and therefore divergence complexity, we used model-based inference and model-based selection to calculate evidence ratios and rank all possible models [ 90- 92].
Based on the unique divergence of ABCCs in T. japonicus, we suggest that each isoform evolved as a new transporter for adaptation and/or speciation, even though pseudogenes should be confirmed with genomic structure comparison and functional characterization.
This is because each pair of paralogous regions can have its own unique divergence level according to their duplication time, whereas all of the orthologous pairs have been diverging over the same amount of evolutionary time.
This method thus trades the ad hoc rate assumptions of the previous methods with two implicit conditions: (i) that subtypes have a unique divergence and (ii) a third, comparable subtype is available to serve as an outgroup.
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Thus, given the number of unique divergence-time classes in t, this determines the probability of prior term p(τ | t).
Most interesting is the fact that GroEL3 showed no conservation of any of the intra-molecular amino acid site pairs coevolutionary relationships when compared to GroEL1 or GroEL2, thus pinpointing its unique evolutionary divergence and probable functional divergence from the other GroEL copies.
Interestingly, the unique functional divergence of the tandemly duplicated A. gossypii RHO1 genes (ABR182W and ABR183W) is conserved in A. aceri.
After CBF duplication, CBF2 experienced selective sweeps in the promoter and coding regions, and this may have resulted in its unique functional divergence which differs from those of CBF1 and -3.
Exemplars have unique (>20% divergence) intervening sequence (Yang and Bennetzen 2009a).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com