In the clinic, the personal history of the unique GLRX5-deficient patient was unremarkable until age 44, when mild anemia and type 2 diabetes were diagnosed.
Immuno-staining of endocrine markers, such as insulin and glucagon, did not reveal distinct features unique to mice deficient for pVHL in β-cells (data not shown).
These findings are not unique, because mice deficient in NOD2, which is strongly associated with CD, are similarly susceptible to a Citrobacter (Kim et al., 2011) and Salmonella (Claes et al., 2014) colitis but not to DSS (Kobayashi et al., 2005).
Another COMT-deficient unique lignan occurred at RT 15.18 min (M+ 530 219 354) and is likely an iso-sinapyl alcohol-phenolic acid conjugate.
Therefore, the mechanisms underlying the etiology of the abnormal hypothalamic-pituitary-ovarian axes in these unique lipoprotein receptor-deficient animal models are likely not identical.
These protective features are unique to ROCK1 deficiency as ROCK2-deficient cells exhibited increased periphery membrane folding and altered cell adhesion.
Particularly important is the unique susceptibility of AAT-deficient individuals to exposure to chemical and particulate environmental agents.
A particular unique subset of COX-deficient Leigh syndrome is French-Canadian Leigh disease (Saguenay-Lac-St-Jean cytochrome c oxidase deficiency [LRPPRC]).
Twenty four-nt sRNAs, which are implicated to derive from intergenic and repetitive genomic regions and mainly guide transcriptional gene silencing, accounted for 48.5% of the total unique sRNAs in P-deficient shoots and 29.4% in P-sufficient shoots.
The unique phenotype of Fhit-deficient cells, with their rapid and prolonged block in S/G2 after UVC or mitomycin C treatment, coupled with drastically reduced apoptotic response, suggests that Fhit loss also contributes to multiple cell programs that are important in the development of precancer and cancer.
