Although each economic evaluation is unique, both the new drug and the comparator drug costs are always included.
The use of a proven dose of captopril and the comparator arms with valsartan alone or in combination with captopril provides a unique test of whether the angiotensin II receptor blocker can make an additional improvement in clinical outcomes beyond angiotensin-converting enzyme inhibitors.
Competition would still exist as the winning tender would be compared with an in-house comparator in March 2014.
The comparator was speculum examination alone.
PES is unique to CF, and was not found causing infection in comparator populations of adults with non-CF bronchiectasis, or community-acquired bacteremia nor during extensive sampling of natural environmental reservoirs or the local hospital sampling [ 7, 12].
In summary, finite element analysis has been used as a noninvasive surrogate biomarker for bone strength and quality, and thereby has provided unique clinical insight into the biomechanical effects of new osteoporosis therapy, and has enabled comparator differentiation and clinical longitudinal predictions of bone strength, thereby enabling decision making in the odanacatib program.
Each death record is associated to a unique number; therefore, we considered a match if the unique identifier was identified by the comparator and also found by the reference standard.
Trypsin digestion of purified A/California/07/2009 rHA uncovered a unique susceptibility of the protein to proteolytic cleavage not found in the seasonal rHA comparators.
Differences were also found between age-matched and size-matched wild-type trout groups (64 mRNAs), with unique mRNA differences for each of the wild-type groups when compared to domesticated trout (Wa: 114 mRNAs, Ws: 88 mRNAs), illustrating an influence of fish developmental stage affecting findings when used as comparator groups to other genotypes.
Use of an active comparator, although preferred, would have posed considerable challenges to keep the study blind because of the unique mode of delivery and smell of methoxyflurane.
The use of an active comparator, although preferred, would have posed insurmountable challenges to keep the study blind because of the unique mode of delivery and smell of methoxyflurane.
