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In this case study, we profile the I-SPY 2 TRIAL (Investigation of Serial studies to Predict Your Therapeutic Response with Imaging And molecular anaLysis 2), a unique breast cancer clinical trial led by researchers at 20 leading cancer centers across the US, and examine its potential to serve as a model of drug development for other disease areas.
These coincide with 8q gains in 50% of the cases in this unique breast cancer subgroup.
This emphasizes the importance of looking at ER-negative breast cancer separately as a unique breast cancer phenotype.
Every case should represent a unique breast cancer patient 2. All must be primary breast cancers 3.
Discriminatory peaks are listed in Table 3. Metaplastic carcinoma is a unique breast cancer subtype, characterized by distinct morphologic feature and poor prognosis [ 23].
Here we have used promoter tiling microarrays and a unique breast cancer metastasis model to provide a whole-genome map of epigenetic changes related to cancer metastasis.
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Although epigenetic alterations are not unique for breast cancer, there are tumor suppressor genes that are frequently methylated and downregulated in breast cancer [ 43, 44].
It is possible that our observed association of CXCR4-tropic HIV is unique to breast neoplasia due to conformational heterogeneity or variable surface expression of CXCR4 epitopes on neoplastic breast duct cells [10], [19].
This is not unique to breast cancer.
In the present study, we have employed a genomic approach to facilitate the exploration of the biologic forces driving age-specific differences unique to breast cancer.
This situation is not unique to breast cancer prognosis, and the description of new expression profiles suggests that it is common to other cancer types or conditions―i.e.e
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com