There are four unique binding sites in tubulin to which taxanes, vinca alkaloids, laulimalide and colchicine bind respectively.
Thus, the RAS/MAPK signaling pathway activates ETS1 and ETS2 by promoting a unique binding interface with p300 or CBP.
The X-ray crystal structure of 4g showed a unique binding mode different from other well known JNK3 inhibitors.
Here, we describe crystal structures of STING CTD alone and complexed with c-di-GMP in a unique binding mode.
Here, we report a unique binding specificity and mode of ligand binding for a family 32 CBM.
The unique binding pocket on HER-2 for pertuzumab provides an important target domain for creation of new anticancer drugs.
Docking studies suggested a unique binding mode of the molecules in the catalytic site of immunoproteasome proteolytic subunits.
The preliminary SAR had been discussed and the unique binding site in SH2 domain was predicted by molecular docking.
The docking study confirmed a unique binding mode in the active site of CDK1B with better score than flavopiridol.
The libraries were sorted against a panel of proteins and yielded multiple unique binding clones against all six antigens tested.
In 2012, our group determined the crystal structure of STING C-terminal domain complexed with c-di-GMP in a unique binding mode (Ouyang et al., 2012).
