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Congenital Dyserythropoietic Anemia type II is an autosomal recessive disorder characterized by unique abnormalities in the differentiation of cells of the erythroid lineage.
Although useful models for studying cancer, our previous analysis of independently cultured strains of a breast cancer cell line (Bahia et al, 2002) revealed unique abnormalities in each variant, suggesting that cell lines may not provide data as reliable and as clinically relevant as that obtained from primary tumour samples.
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If the median of the adjacent data is twice as large as or larger than the median of the abnormal region, it is deemed likely that there is an adjacent unique abnormality and the initial boundary remains, unless a CUSUM minimum was detected.
"It can be a unique abnormality in each case.
It is an extremely rare and unique abnormality occurring in less than 1 per 10,000 births worldwide.
Although no unique abnormality characterizes all MM, those harbored by the plasma cell (PC) in each patient represent clonotypic markers to identify clonal relationships within that MM patient.
According to cytogenetic abnormalities, the 60 patients were classified into five subtypes: 17 patients with t(4 14); 11 with t(11 14); four with t(14 16); 15 with RB DEL (RB deletion as a unique abnormality, RB deletion, and P53 deletion); and 13 with NFISH Normal Fishh).
These EOC cell lines were derived from ovarian cancer samples from chemotherapy naïve patients and have been shown to exhibit unique karyotypic abnormalities [ 2].
The first unexpected finding occurred when the karyotypes of TPC-1 and FB2 were compared, as several unique cytogenetic abnormalities were shared by the two cell lines.
In turn, impaired kidney function, even within the normal range, may promote cardiovascular disease and mortality by leading to oxidative stress, anemia, disturbed mineral metabolism, and other unique metabolic abnormalities (35).
Identification of optimal dietary protein intake is further complicated in DKD by the fact that kidney disease confers unique metabolic abnormalities that can include alterations in mineral metabolism, metabolic acidosis, anemia, vitamin D deficiency, loss of lean muscle mass, and susceptibility to malnutrition.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com