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This was done to transfer a representative sample of the age structure of the population at each time and avoid unintentional selection of some specific life history strategies.
As in any partial list of ESTs (i.e. not genome-wide), there might have been an unintentional selection of particular functional categories of genes, but we believe that our gene set is large enough to be representative of the genome as a whole.
The relatively high number of genomic regions with skewed segregation towards the elite parent detected in the 97103 × PI 296341-FR RIL population reinforces the hypothesis that such distortion likely originated from unintentional selection of genes in the elite parent that may be associated with fruit and seed production (especially ease of production) during RIL line development [ 20].
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Five studies described the use of selection criteria, mostly on NPS, and in eight other studies there might have been an indirect (unintentional) selection on pain, NPS or functioning.
First, nonrandom sampling or artificial breeding can cause unintentional selection on particular traits.
Similarly, selection bias may result from the unintentional selection for differing characteristics among patients who, for example, receive a particular diabetes treatment.
There are some obvious limitations of this study, including the small number of patients analysed, the possibility of unintentional selection bias and the wide variety of treatments regimens used.
The possibility of (unintentional) selection bias should be addressed.
The present study is a retrospective analysis, and thus an unintentional selection bias for a subset of patients is possible.
Those evolutionary effects that have been considered to date tend to be the result of direct intentional or unintentional selection (e.g. harvest and hydropower effects Ricker 1981; Quinn and Adams 1996; Achord et al. 2007).
The unintentional selection differential, which occurred over the 11 generations of selection in the C line was small (-1.09 fertile eggs).
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