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Therefore, for the first step of selecting images, we manually eliminated the images with dark background and uninformative images (Supplementary Fig. 4) from the training set.
Our results confirm that the proposed time-course pipeline leads to highly successful expression pattern classification, despite the presence of uninformative images, registration errors and missing data in considerable amounts.
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The abovementioned procedure might produce an uninformative image region comprising low distinctive features.
By contrast, simple mechanistic compression of pixels that is used currently in most biological network viewers makes network images uninformative.
In contrast, the others (random (black), wye (magenta), and foot (cyan)) are uninformative for natural images, and contributed little to the MCDI.
These two operations largely remove small-scale features that form the uninformative background of the image.
First, it reduces the dimensionality of the space of image statistics that need to be considered, since it can be applied to binarized images, and it separates informative from uninformative statistics (Tkačik et al., 2010).
We agree that it would have been a good control to include an uninformative third‐order correlation, but previous work on natural image statistics did not identify any such configurations (and didn't seek to do so).
Second, the approach enables rigorous tests of theoretical predictions, since the individual kinds of informative and uninformative multipoint correlations can be isolated in synthetic image sets (Victor and Conte, 2012).
Low-resolution microscopy images of the structure as a whole were uninformative.
Without a reference range, the ratio is relatively uninformative.
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