This low-confidence CNV call encompasses less than 0.3% of the associated region and does not impact genic exons and as such is an unimportant variation.
Large samples will be required, and genetic heterogeneity, combined with the huge volume of (mostly unimportant) variation uncovered, poses extreme challenges for data interpretation even given knowledge about 'background' variation provided by the 1000 genomes project.
That is not to say such variation is unimportant; UTR variation can affect many aspects of regulation (e.g. mRNA stability [ 30, 31] and protein translation [ 32, 33]) and while the sequences underlying these processes are largely cryptic at the present time, we predict they will be considered a more significant source of functional variation in future.
Each group needs to be big enough to make inter-subject variation unimportant.
These results have important implications for the conservation of threatened species and management practices that may historically have overlooked phenotypic variation as unimportant noise around mean values of interest.
From our perspective, the variation is unimportant because each attribute contains an implicit clause of ceteris paribus: all other things being equal, humility is generally now seen to be desirable and its importance can be assessed alongside that of other human attributes.
Evidently, in the presence of 2.5 mg/d medroxyprogesterone acetate, these risk variations are quite unimportant.
Epistasis appears to be relatively unimportant as a source of variation.
Despite the importance and near ubiquity of such variation, many students have a tendency to dismiss variation within species as unimportant and focus their attention on traits that individuals in a species share (for a review, see Solomon and Zaitchik, 2012).
This worldview, called "essentialism," dismisses variation between individuals as unimportant, and makes natural selection, speciation, and macroevolution seem impossible.
As Darwin (1859) put it, "Any variation which is not inherited is unimportant for us".
