Currently there is no unifying hypothesis explaining the alterations in sleep observable in patients with bipolar disorder and management is often difficult though vital.
Rather than choosing a small, manageable project, she had set her sights on tackling an ambitious, unifying hypothesis linking the brain and the immune system to explain both normal brain development and disease.
In it, the authors attempt to discuss progress that has been made in this arena as well as the possibility that some point (or points) along a G protein signaling cascade represent a molecular target for antidepressant therapy that might lead toward a unifying hypothesis for depression.
A "unifying hypothesis for Alzheimer's disease" has been suggested, according to which the aberration of a single post-translational modification, such as protein phosphorylation, might underlie both pathologies [2] [4].
Insulin resistance has been the most accepted and unifying hypothesis to describe the pathophysiology of the metabolic syndrome [ 1].
Wnt signaling has also been linked to neurodegenerative disease indeed, dysregulated Wnt signaling has been suggested as a unifying hypothesis underlying Alzheimer's disease (19).
The symptoms reported in the larynx are very common in this syndrome, and the authors justify their "unifying" hypothesis because of the greater density of laryngeal cough receptors.
A unifying hypothesis invokes the possibility that the insulator has a dual function, i.e., the insulator can provide a physical barrier and, that as a generator of three-dimensional structures, it can also target distal cis-regulatory elements.
The oxidative stress concept has been combined with impaired GTN biotransformation in a unifying hypothesis explaining nitrate tolerance and endothelial dysfunction upon exposure of blood vessels to GTN (Münzel et al., 2011).
Evidence for the involvement of other proteins such as lipoprotein[Lp] (a) [ 11] was available in the TARF cohort or of cystatin C and glycated hemoglobin in studies from other populations, upon which a unifying hypothesis of autoimmune activation underlying diverse chronic diseases was put forward by Onat and Can [ 12], further explained in the Discussion.
Mitochondrial overproduction of superoxide in hyperglycemia has been suggested as the "unifying hypothesis" for the development of diabetic complications (2).
