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Furthermore, content uniformity testing of the studied pharmaceutical formulations was also conducted.
The sensitivity of the proposed method allows its application for content uniformity testing.
Hence, the method was applied to the determination of EBS in its tablets, and further for content uniformity testing.
The results demonstrated excellent drug uniformity as shown in table 4. Table 4 Results of content uniformity testing of Sirdalud® tablets using the proposed method.
Therefore, both the ultra-high growth accuracy and the uniformity testing methodology are necessary for developing nowadays devices of that kind.
Transmission Raman spectroscopy is a potent new tool for content uniformity testing in pharmaceutical manufacturing enabling rapid bulk sampling of a material by non-destructive means.
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Apart from conducting uniformity tests based on the uniform residuals from the transformation (23), such as the KS-test as we have done, we can compare the Akaike information criterion (AIC) and Bayesian information criterion (BIC) between the two models.
The drug content uniformity test was performed to ensure the uniform distribution of the drug throughout the films.
Due to the high sensitivity of the proposed method for the determination of tizanidine the content uniformity test was applied.
Tablets with ethylcellulose gradients showed acceptable mechanical and pharmacotechnical properties, as indicated by crushing strength, friability, and content uniformity tests.
The method was successfully applied for determination of the studied drugs in their dosage forms; and to the content uniformity test of tizanidine in tablets.
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