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For each comparison we checked the assumption of uniform differences and uniform variability.
Bland & Altman plots confirmed this with a random scatter about zero as would be expected if there is no difference between two measurements and uniform variability throughout the range of measurements.
For dense pharmacokinetic data, the combined additive and proportional error models are often utilized because it broadly reflects assay variability, whereas for pharmacodynamic data (which often have uniform variability across the range of possible values), an additive residual error may be sufficient.
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The primary colorectal tumors presented a high variation in LINE-1 methylation among different samples (Figure 2A), and the stratification of these colorectal tumors and their normal adjacent tissue reveals a non-uniform variability in LINE-1 methylation.
For acids, the differences between diff (log PN − I) and diff p Ka′′ are fairly uniform, considering the variability found with log PI determinations.
Strikingly, even on a uniform genetic background, variability in the penetrance and severity of the mutant phenotypes was observed between the different double-heterozygote combinations.
Finally, the expertise of the radiologists, like the expertise of all physicians involved in the care of pancreas cancer, is not uniform, and this variability may lead to differences in the approach to the same patient at multiple institutions.
The critical model parameters are the mean accumulation rates for the target and non-targets (v T and v NT, respectively), the upper limit of the uniform starting point variability (s), the response threshold (z), and the accumulation rate standard deviation (σ v).
The key histological finding in this study was that the preexisting tissue expression of MMP-2 in the SV wall of normal macroscopic appearance was not uniform, and this variability could be at least associated with the long-term CABG outcomes.
Whether that uniform yet wholly discretionary variability defeats or enables class certification of misclassification claims is an important, recurring and unsettled fundamental issue in this new context.
First-guess estimates of bathymetry were derived from SWOT observations assuming a uniform spatial depth; bathymetric variability was modeled using an exponential correlation function.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com