Sentence examples for uniform activation from inspiring English sources
One possible explanation for the discordance between these results and the hypothesized PC1-TSC2-TOR signaxisg axis (which would predict uniform activation of mTOR in PKD1 cysts) is that mTOR is initially uniformly active, but that fibrosis and consequent hypoxia in end-stage disease inhibit mTOR.
This demonstrated that uniform activation of endogenous PI3K is sufficient to trigger symmetry breaking as well as cell migration.
We then tested whether uniform activation of PI3K, without any receptor input, causes cell polarization (Fig. 1C, left).
We show that uniform activation of endogenous PI3K is sufficient to polarize previously unpolarized neutrophils and trigger effective cell migration.
Thus, uniform activation of endogenous PI3K is sufficient to cause symmetry breaking and trigger migration while the symmetry breaking is lost at the level of Rac.
In order to understand the different roles of PI3K and Rac in polarization, we monitored the spatial distribution of PIP3 following uniform activation of either PI3K or Rac (Fig. 5A).
In a recent study, Stalker et al. suggested a new model of thrombus structure, taking into account that non-uniform activation pattern.
Neural mechanisms that underlie the fluctuation around an average value during isometric actions, involve motor unit properties and non-uniform activation of different muscles (Enoka et al. 2003).
Synchronization of Ca2 + sparks during systole depends on the nearly uniform cellular activation of LCCs and the likelihood of local LCC openings triggering local Ca2 + sparks (ECC fidelity).
The results showed that the structure of Ni P coating was amorphous, the Ni P coating was very meticulous and uniform, the activation coating was mainly MgF2 and Mg2P2O7, and comparing with magnesium substrate, the corrosion potential of magnesium alloys increased by about 1.1 V and the corrosion current density declined obviously.
At no intermediate concentration did we observe polarization or migration following uniform Rac activation (Fig. 3).
