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This information model is aimed at the identification of biobanks; unification of databases; and objectification of the information, samples, and related studies – to create a completely new 'bio-object infrastructure' within the EU.
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"The patient has to be informed and willing to share the information that researchers are collecting – for the benefit of the patient and anyone else affected by the same problems," said Floridi, who is also chair of the Ethics Advisory Board of the European Medical Information Framework, the largest EU project on the unification of biomedical databases.
Unification of the different databases was made possible by leveraging the greater dynamic range of the color ratio pyrometry soot diagnostic.
The reliance on physical entities and sets of physical entities as our backbone is especially useful for data integration since it allows unambiguous unification of many entities from different databases based on their physical properties.
Both of these data, objects can be resident in a contact database, but unification of these two messaging methods would greatly simplify and accelerate mobilizing the ability to send a message to anyone from anywhere.
And the unification of consumer lenders' jealously guarded proprietorial credit databases into a national whole would remove an important barrier to entry.
Moreover, different databases might have different policy regarding unification of distinct disease manifestations.
The aggregator approach does not perform any unification of the underlying pathways--viz., if n source databases each contains information on a particular pathway, that pathway is presented by the aggregator as n separate pathways.
Clinical trials will be mined for each disease before database generation, to allow for effective unification of entries representing the same trials performed at different locations.
Learning from experience gained in implementing version 1.0, database cross-references now use the extended PSI-MI CV2.5 controlled vocabulary to ensure consistent naming of external database resources, avoiding problems with the unification of, for example, 'Swiss-Prot', 'swissprot', 'sp', 'uniprot' and 'uniprotkb'uniprotkb
Validation against family definitions in the manually curated databases SCOP and PFAM indicates almost perfect unification of various large domain families while contamination by unrelated sequences remains at a low level.
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