We cannot however exclude the possibility that this mutation also affects other yet-unidentified function of the SADH domain.
Furthermore, given the fact that not all of the siRNA, shRNA or ASO sequences showed significant homology to the IL13ra2 or IL1rn sequences (Figure 4), these common down-regulations may be due to an unappreciated biological consequence of Gαi2 or Gβ2 depletion and shed light onto the unidentified functions of these G-protein subunits.
In the present study, we demonstrate a previously unidentified function of HMGA2 protein to induce cellular apoptosis in primary cells.
It is also possible that the inhibition of DC maturation is occurring through an as yet unidentified function of vhs.
Alternatively, these epistasis results may reflect changes in an as yet unidentified function of Msh2-Msh3, perhaps one that is performed in conjunction with Rad59.
Our present results provide important insights into the regulation of Notch1 expression under the stress condition, and into periostin as a regulator of Notch1 expression, which is another unidentified function of periostin.
Our data showing that AEBP1 is upregulated in at least a proportion of BRAF (V600E) melanomas that had acquired resistance to PLX4032, and that inhibition of AEBP1 restores its sensitivity to PLX4032 in resistant cells uncover a previously unidentified function of AEBP1 in association with BRAF inhibitor resistance.
Although CSB has been shown to interact with some of the functional units of basal transcription factor TFIIH and RNA polymerase elongation complexes, identification of additional proteins and protein complexes interacting with CSB would help to unravel some of the yet unidentified functions of CSB.
Alternatively, NbNAG may have additional, yet unidentified, functions, of which disruption induces PCD in a plant cell.
This result suggests important but as yet unidentified functions of ABA/G-protein co-regulation in mesophyll cell physiology.
The amenability to efficient RNAi treatments, rapid development of clear phenotypes and established cell biological readouts, combined with new post-genomic technologies, make planarians an outstanding tool for gene discovery and can reveal unidentified functions of known and unknown genes involved in human regeneration, development and disease.
