Unfortunately we found that the understanding of trachoma signs and symptoms was often limited, even among health workers, which may have led to exclusion of highly trachoma endemic villages from the TRA, in turn leading to an underestimate of the problem.
Unfortunately, the advances of the understanding of DC vaccine have not been paralleled by development of a means of actually inducing tolerance to the autoantigens.
Unfortunately, the poor understanding of the development of HCC metastasis has been the main obstacle for the improvement of HCC therapy (Shuqun et al, 2004; Sun et al, 2007; Amarapurkar et al, 2008; Lim et al, 2008; Ramaiah and Rittling, 2008).
Despite identification of the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel as the causative gene for CF and having a mouse model where CFTR has been disrupted [ 58], for over 20 years, little advancement has been made in the understanding of CF. Unfortunately, disruption of CFTR in the mouse does not result in a human CF phenotype [ 59- 61].
Unfortunately, it had, important consequences, limiting the spread of the understanding of the concept of information, especially in its involvement in biological systems.
Unfortunately, no long-term monitoring results have been reported, limiting the understanding of microbial activity after treatment with these formulations.
Unfortunately, this applicative knowledge is not paralleled by a correspondent increase in the understanding of the basics of reproductive biology.
Unfortunately, the differences in aa-sequence with that of the other Trichoderma hydrophobins do not provide a clear clue as to the understanding of its function.
Unfortunately our understanding of the underlying mechanisms of NO-induced headache is still very limited.
Unfortunately, our understanding of the disturbance dynamics of past fires is incomplete, and many open questions exist relevant to these concepts and the related methods.
