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"Unfortunately, generally speaking, unless there are reasons and national security interests involved in both parties, then they don't work".
That has, unfortunately, generally been the case since the war officially ended in 2002, and is one of the main reasons why progress on the human rights front since then has been so deeply unsatisfactory.
The APL derived from the MBP encephalitogenic fragment (MBP82 98) has proved promising in inhibiting MS progression in patients with the HLA-DR2/DR4 haplotype but, unfortunately, generally failed in phase 3 of the clinical trial (5).
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Unfortunately, no generally agreed estimates exist.
Unfortunately, you generally don't win them all.
Unfortunately, it generally suffers of lack of precision and robustness.
Unfortunately, no generally applicable representation of invariant chemical space has yet been reported [25].
Unfortunately, NFC generally requires an accompanying chip built into the phone itself.
Unfortunately, they generally take a lot more effort to create, which puts them out of reach for some companies.
Unfortunately, it generally requires sampling the operator very many times at a significant cost, especially when the model is expensive to evaluate.
Unfortunately, students generally lack "tree-thinking" skills and are often unmotivated to explore these concepts using typical classroom exercises that feature taxa unknown to students or simulated datasets.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com