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Abramovich, however, has never appeared the sentimental sort and there can be no doubt this wretched, totally unforeseen sequence of bad results has put Mourinho in danger.
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It is this unforeseen sequence of events, resulting from what accident theorists call the "tight coupling" of complex interacting systems, that causes accidents.
Although subgroup analyses of cohorts that had alternate cycle-1 dosing sequences were not preplanned, unforeseen safety issues prompted a more detailed evaluation.
Examples of potential problems include unforeseen immune reactions or altering the wrong sequence of DNA — so-called off-target effects.
It is unlikely that the use of new sequencing technologies per se would introduce unforeseen biases into expression libraries, but our findings suggest that researchers will need to verify this.
Top down search algorithms have capitalized on this by allowing expanded precursor mass tolerances that can accommodate unforeseen PTMs and mass shifts (including subtractive modifications like sequence truncations or incorrect start sites).
For small RNA sequencing by Illumina technology, sequence features and/or post-transcriptional modification may be important features causing unforeseen biases determining an underestimate of abundance of specific miRNA families.
Although it is more difficult to analyze novel genomic sequence in comparative studies, the novel sequences may become starting material for unforeseen biotechnology projects or discoveries in microbial evolution.
The recent advances in novel sequencing and hybridization technologies [ 16, 17] have permitted an unforeseen depth in detection of transcriptional activity.
Genome sequencing will greatly expand this gene catalog, and may also uncover unforeseen targets for novel and specific acaricides, such as divergence in metabolic pathways between mites and bees or the discovery of important microbial interactions.
Alternatively, sequencing with a different technology may have changed the pattern in an unforeseen way.
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