Therefore, it's helpful to frame the scope broadly and allow for unforeseen change and modification rather than establishing a set timeline with a strict exit/sunset clause.
Due to planning modifications, construction delays, or unforeseen events, schedules are often not up-to-date and must be continuously adapted.
The structure used to encapsulate the tests allows developers to ensure that recent code modifications have not resulted in unforeseen impacts on program predictions, and allows users to check for themselves against benchmarks.
Top down search algorithms have capitalized on this by allowing expanded precursor mass tolerances that can accommodate unforeseen PTMs and mass shifts (including subtractive modifications like sequence truncations or incorrect start sites).
The third reason for the NIH position is "serious and unquantifiable safety issues" – the risk of unforeseen side-effects in babies born after gene modification.
For small RNA sequencing by Illumina technology, sequence features and/or post-transcriptional modification may be important features causing unforeseen biases determining an underestimate of abundance of specific miRNA families.
There have been numerous delays due to design modifications, called change orders, that Mr. Simon said were unforeseen.
A British official who was critical of the support given to Abd al-Rahman at this time later wrote that some changes were "a modification of policy deliberately proposed; others... the unforeseen consequence of action taken; others, perhaps the majority, appear superficially to represent a gradual drift, of which the Government was at the time unconscious".
Well-designed research over the last 10 years has identified unforeseen substrate heterogeneity for the AlkB homologs, including novel reversible methyl modifications in RNA.
For example, the authorities could ask the companies to recall trucks for modifications, to redesign engines on future trucks or to compensate for the unforeseen pollution in some other way, such as subsidizing low-pollution vehicles in areas with especially dirty air.
This is a point that has gained credence in the sociotechnical literature (Leveson 2011 ), and that lies at the root of the 'Law of Unintended Consequences', i.e. the notion that modifications to the structure or behaviour of complex sociotechnical systems commonly result in unforeseen outcomes and side effects (Pasmore 1988 ).
