Typically, most drug development processes suffer from planning problems, as well as delays in development, unforeseen activities, cost overruns, and losses resulting from high turnover.
Another specific stipulation in the donors' clarifications stated, "As it is impossible to envision future requests or unforeseen circumstances, all activities not explicitly identified in this document are inconsistent with donor intent and should not be undertaken or allowed".
Clues to the non-innocent nature of many ionic liquids are contained in the reports of altered reactivity of dissolved substrates, unexpected catalytic activity and unforeseen by-product formation.
This was unforeseen since MAO-B activity was inhibited during smoking (P<0.00001).
A large number of new drug candidates fail in clinical trials for a variety of reasons, including insufficient activity or unforeseen toxicity.
The celebration of Reindeer Herders Day and other festivals at the end of the winter period often bring unforeseen love and sexual activity.
In this case, silencing of Luc should be due to transfer of miR-222 and not due to unforeseen changes in endogenous miRNA activity.
An unforeseen observation was the significant activity observed at time "0," that is, promptly after administration of the gels; this could be attributed to the 10-day pretreatment of the animals with doxepin based formulations before the actual measurements were undertaken.
The unforeseen results exhibit surprisingly higher ORR activity for carbon catalyst obtained from yellow leaves LY-10000) compared with one prepared from green leaves collected in summer, LG-10000).
The availability of powerful knowledge discovery techniques has allowed the exploration of a greater number of possible relationships that could not be evaluated manually, the consequence of which is that modelling activity now allows previously unforeseen hypotheses to be generated.
