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A descending circular ramp the length of a football field tells the story of unfolding time, from the Big Bang 13 billion years ago to the present.
The high-force regime is characterized by barrierless unfolding, and the unfolding time approaches a limit of ∼10 μs for the highest forces we studied.
Thus, a more complete description of landscape of protein native interactions can be mapped out if unfolding time data are collected at several values of fS and fQ.
Because the physical model in the fit affects the characteristic unfolding time, these results have important implications on our understanding of the biological function of proteins.
And since the rates of direct and reverse reactions are equal at the equilibrium point (as follows from the physical "detailed balance" principle), the estimated folding time can be derived from the estimated unfolding time.
And since all of that is being offered through unfolding time, the sentences begin to wind around themselves, the way thoughts do.
Similar(44)
The unfolding time-force relation τ(F) indicates that the force-induced unfolding behavior of filamin can be characterized into three regimes: barrier-limited low- and intermediate-force regimes, and a barrierless high-force regime.
In the current experimental setup (using either atomic force microscopy or laser optical tweezers) the distribution of unfolding times, P t), is measured by applying a constant stretching force fS from which the apparent fS-dependent unfolding rate is obtained.
The historical time that narrative presents, i.e., human time as it unfolds in time, is an interpersonal, public time.
Experience the unfolding of time," Pitt intones as stars erupt and waterfalls tumble in the Voyage of Time trailer.
His letters, unfolding over time, enable these contradictions and alternative stories to coexist.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com