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The A−B loop and the unfolded part of helix B of apo DHFR is refolded on forming the binary complexes with obvious implications for cooperative binding.
Bend the end of the unfolded part 90 degrees, so it's still parallel to the rest of the paper clip.
You shouldn't pinch the paper too hard, or hold down the unfolded part, or you won't be able to snap it.
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Based on the result that UFD-2 preferentially ubiquitinates unfolded parts of the UNC-45 myosin-binding domain, we asked whether unfolded myosin presented by the UCS domain of UNC-45 could be targeted as well.
Hold the top right corners of the unfolded section (the parts that are on the same side of the popper as the loops).
A possible scenario would involve an unfolded region, which is part of a largely folded monomer.
When you're snapping the popper open, you'll be releasing the unfolded section, and therefore the air pockets in the unfolded section, so you have to give this part freedom to move.
In contrast, in fibrils arising from "direct fusions" between the oligo-Ala stretch and CspB (fusions C, Fig. 1), the CspB moiety was unfolded, presumably because part of it was recruited to the fibrils [19].
It should constitute a stably folded, compact domain and possess a well-ordered surface, as unfolded and flexible parts prevent crystallization for entropic reasons [2].
To reduce the computation time, the part is unfolded properly on the flat sheet and treated as a 2D problem.
The part that unfolded in open court included many bizarre moments, including a Michael Jackson impersonator and a man who asked for El Chapo's autograph.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com